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  • 林文昌 教授
  • 職稱:    研究員, 中央研究院生物醫學科學研究所
  • 學歷:    美國凱斯西儲大學分子生物與微生物學博士
  • 辦公室:  中研院生醫所N610室
  • 電話:    886-2-27899148
  • Email:
  • 個人網頁http://
  • 基因表現資料庫及調控分析 (Gene Expression Database and Analysis)
  • 腫瘤生物學 (Cancer Biology)
    1. Ho MR, Tsai KW, Chen CH, Lin WC. dbDNV: a resource of duplicated gene nucleotide variants in human genome. Nucleic Acids Res. 2011 Jan;39
    2. Ho MR, Lou YC, Wei SY, Luo SC, Lin WC, Lyu PC, Chen C. Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. J Mol Biol. 2010 Oct 1;402(4):682-95.
    3. Tsai KW, Hu LY, Wu CW, Li SC, Lai CH, Kao HW, Fang WL, Lin WC. Epigenetic regulation of miR-196b expression in gastric cancer. Genes Chromosomes Cancer. 2010 Nov;49(11):969-80.
    4. Tsai KW, Chan WC, Hsu CN, Lin WC. Sequence features involved in the mechanism of 3' splice junction wobbling. Ho MR, Chen CH, Lin WC. Gene-oriented ortholog database: a functional comparison platform for orthologous loci. Database (Oxford). 2010;2010:baq002. Epub 2010 Feb 10.
    5. Li SC, Chan WC, Hu LY, Lai CH, Hsu CN, Lin WC. Identification of homologous microRNAs in 56 animal genomes. Genomics. 2010 Jul;96(1):1-9
    6. Chan WC, Liang PH, Shih YP, Yang UC, Lin WC, Hsu CN. Learning to predict expression efficacy of vectors in recombinant protein production. BMC Bioinformatics. 2010 Jan 18;11 Suppl 1:S21.
    7. Tsai KW, Kao HW, Chen HC, Chen SJ, Lin WC. Epigenetic control of the expression of a primate-specific microRNA cluster in human cancer cells. Epigenetics. 2009 Nov 16;4(8):587-92.
    8. Ho MR, Jang WJ, Chen CH, Ch'ang LY, Lin WC. Designating eukaryotic orthology via processed transcription units. Nucleic Acids Res. 2008 Jun;36(10):3436-42.
    9. Li SC, Shiau CK, Lin WC. Vir-Mir db: prediction of viral microRNA candidate hairpins. Nucleic Acids Res. 2008 Jan;36(Database issue):D184-9.
    10. Li SC, Tang P, Lin WC. Intronic microRNA: discovery and biological implications. DNA Cell Biol. 2007 Apr;26(4):195-207.
    11. Ho MR, Lou YC, Lin WC, Lyu PC, Huang WN, Chen C. Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation. J Biol Chem. 2006 Nov 3;281(44):33566-76.
    12. Li SC, Pan CY, Lin WC. Bioinformatic discovery of microRNA precursors from human ESTs and introns. BMC Genomics. 2006 Jul 3;7:164.
    13. Chun-Hung Lai, Ling-Yueh Hu, and Wen-chang Lin. 2006. Single amino-acid InDel variants generated by alternative tandem splice-donor and -acceptor selection. Biochem. Biophys. Res. Commun. 342: 197-205.
    14. Chew-Wun Wu, Hwa-Li Kao, Anna F.-Y. Li, Chin-Wen Chi, and Wen-chang Lin. 2006. Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. Cancer Letters. In press.
    15. Chew-Wun Wu, Jen-Hao Chen, Hwa-Li Kao, Anna F.-Y. Li, Chun-Hun Lai, Chin-Wen Chi, and Wen-chang Lin. 2006. PTPN3 and PTPN4 Tyrosine-Phosphatase Expression in Human Gastric Adenocarcinoma. Anticancer Res. 26: 1643-1650.
    16. Ling-Yueh Hu and Wen-chang Lin. 2006. An Efficient Strategy to Identify Early TPA-responsive Genes During Differentiation of HL-60 Cells. Submitted.
    17. Kuo-Wang Tsai and Wen-chang Lin. 2006. Subtle Wobble-splicing Transcript Isoforms Examined by a High-throughput Ultrasensitive Method: Junction-SNP Responsible for Spliced Variants’ Heterogeneity. Submitted.
    18. Sung-Chou Li, Chao-Yu Pan, and Wen-chang Lin. 2006. Bioinformatic Discovery of MicroRNA Precursors and Their Target Genes from Human ESTs and Introns. Submitted.
    19. Ling-Yueh Hu, Chun-Hung Lai , Jian-Yuan Chiu, and Wen-chang Lin. 2005. Functional variants /non-synonymous cSNP discovery by the CGI bioinformatic tool. J. Genetics Mol. Biol. 16: 56-62
    20. Ling-Yueh Hu, and Wen-chang Lin. 2005. Identification of early TPA-responsive genes during differentiation of HL-60 cells. The 45 annual meeting of the American Society of Cell Biology, San Francisco, USA. December 2005.
    21. Chew-Wun Wu, Anna F.-Y. Li, Chin-Wen Chi, and Wen-chang Lin. 2005. Protein tyrosine-phosphatase expression profiling in human gastric cancers. Asia Pacific Cancer Conference, Seoul, Korea. Septembers 2005.
    22. Meng-Ru Ho, Yuan-Chao Lou, Wen-chang Lin, Ping-Ching Lyu and Chinpan Chen. 2004. Letter to the Editor: 1H, 13C, and 15N resonance assignments and secondary structure of human pancreatitis-associated protein (hPAP). J. Biomol NMR. 30: 381-382.
    23. Jeff Yi-Fu Chen, Yih-Leong Chang, Yu-Chen Yu, Chuan-Chuan Chao, Hsiao-Wei Kao, Chen-Tu Wu, Wen-Chang Lin, Jeng-Yuh Ko, and Yuh-Shan Jou. 2004. Specific Induction of the High-molecular-weight Microtubule-associated Protein 2 (hmw-MAP2) by Betel Quid Extract in Cultured Oral Keratinocytes: Clinical Implications in Betel Quid-associated Oral Squamous Cell Carcinoma (OSCC). Carcinogenesis. 25: 269-276.