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生技產業創新創業人才培育課程
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黃智生

l 職稱:副教授

l Address:

112 台北市北投區石牌立農街二段155號 國立陽明大學醫技系

      Institute of Biotechnology in Medicine, National Yang-Ming University ,

      No.155, Sec.2, Li-Nong Street, Taipei 112,

l Tel: +886-2-2826-7148

l Fax: +886-2-2826-40

l E-mail: jchuang2@ym.edu.tw

 

l 學歷

Ø 德州大學蓋維斯頓醫學分校 實驗病理學博士

Ø 陽明大學醫技系 學士

 

l 現任

Ø 陽明大學醫技系 副教授

Ø 國家衛生研究院感染症與疫苗研究所 兼任助研究員

 

l 教授科目

免疫學、高等生物技術 、臨床血清免疫學、血庫學、血液學實驗、流式細胞儀技術之應用

 

l 實驗室研究方向

Ø 禽流感感冒病毒與樹突狀細胞之間的交互作用

Ø 大腸直腸癌調控癌症轉移與幹細胞的基因研究

Ø 自體免疫小鼠疾病模型的建立

Ø 諾羅病毒疫苗載體的開發

 

l 研究著作

Ø Luong, H.M., Wang, S.F., Trao, V.T., Chen, M., Huang, J.C., Cam, P.D. Lin, Y.T. and Chen, Y.M. Retrospective survey of avian influenza H5N1 infection in Northern Vietnam by using a combinational serologic assay. Health2012, 4:974-982

Ø Hwang, K.P., Wu, F.T., Bányai, K., Wu, H.S., Yang, D.C., Huang, Y.C., Lin, J.S., Hsiung, C.A., Huang, J.C., Jiang, B., and Gentsch, J.R. Identification of porcine rotavirus-like genotype P[6] strains in Taiwanese children. J Med Microbiol. 2012 61(7)990-997.

Ø Wu, F.T., Bányai, K., Huang, J.C., Wu, H.S., Chang, F.Y., Hsiung, C.A., Huang, Y.C., Lin, J.S., Hwang, K.P., Jiang, B., and Gentsch, J.R. Human infection with novel G3P[25] rotavirus strain in Taiwan. Clin Microbiol Infect. 2011;17(10):1570-1573

Ø Wu, F.T., Banyai, K., Huang, J.C., Wu, H.S., Chang, F.Y., Yang, J.Y., Hsiung, C.A., Huang, Y.C., Lin, J.S., Hwang, K.P., Jiang, B.,and Gentsch, J.R. Diverse origin of P[19] Rotaviruses in children with acute diarrhea in Taiwan: Detection of novel lineages of the G3, G5, G9 VP7 genes. J Med Virol 2011, 83 (7):1279-1287

Ø Lee, C.W., Leu, S.J., Tseng, R.Y., Wang, S.F., Tsai, S.C., Sun, K.H., Chen, R.H. and Huang, J.C.* Latent membrane protein 1 of Epstein-Barr virus regulates death associated protein kinase 1 in lymphoblastoid cell line. Virology 2011, 413(1):19-25

Ø Chang, Y.F*., Wang, S.F.*, Huang, J.C.*, Su, L.C., Yao, L., Li, Y.C., Wu, S.C., Chen, Y.M., Hsieh, J.P. and Chou, C. Detection of swine-origin influenza A (H1N1) viruses using a localized surface Plasmon coupled fluorescence fiber-optic biosensor. Biosens Bioelectron. 2010 26(3):1068-1073

Ø Wang, S.F., Yao , L., Liu, S.J., Chong, P., Chen,Y.M., Huang, J.C.* Identifying conserved DR1501-restricted CD4+ T cell epitopes in avian H5N1 hemagglutinin proteins. Viral Immunol. 2010 23(6):585-593

Ø Huang, J.C., Chang, Y.F., Chen, K.H., Su, L.C., Lee, C.W., Chen, C.C., Chen, Y.M., and Chou, C. Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in human serum using a localized surface plasmon coupled fluorescence fiber-optic biosensor. Biosens Bioelectron. 2009, 25(2):320-325

Ø Wang, S.F., Lee, Y.M., Chan, Y.J., Liu, H.F., Yen, Y.F., Liu, W.T., Huang, J.C*., and Chen, Y.M. Influenza A Virus in , 1980-2006:Phylogenetic and antigenic characteristics of the hemagglutinin gene. J Med Virol 2009, 81 (8):1457-1470

Ø Peng, S.Y., Chu, T.H., Wang, I.C., Chung, W.C., Yu, K.W., Tsaihong, J.C., Huang, J.C., and Fan, P.C. Infection of normal C3H/HeN mice with Taenia saginata asiatica oncospheres. Res Vet Sci 2009;86(2):261-266

Ø Wang, S.F., Chen, K.H., Thitithanyanont, A., Yao , L., Lee, Y.M., Chan, Y.J., Liu, S.J., Chong, P., Liu, W.T., Huang, J.C.*., and Chen, Y.M. Generating and characterizing monoclonal and polyclonal antibodies against avian H5N1 hemagglutinin protein. Biochem Biophy Res Commun 2009;382(4)691-696

Ø Song, Y.C., Sun, G.H., Lee, T.P., Huang, J.C., Yu, C.L., Chen, C.H., Tang, S.J., Sun, K.H. Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalization via electrostatic interactions. Eur J Immunol. 2008; 38 (11):3178-3190

Ø Lee, T.P., Leu, S.J., Huang, J.C., Song,Y.C., Jhou, R.S., Tang,S.J., and Sun, K.H. Anti-ribosomal P autoantibody triggers IL-10 over-production via PI3K-dependent signaling pathways in LPS-activated macrophages. Immunology. 2008;127(7):91-102

Ø Wang, S.F.*, Huang, J.C.*Lee, Y.M., Liu, S.J., Chan, Y.J., Chau, Y.P., Chong, P., and Chen, Y.M. DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans. Biochem Biophys Res Commun. 2008.373(4):561-566

Ø Sahu, G.K., McNearney, T., Evans, A., Turner, A., Weaver, S., Huang, J.C., Baron, S., Paar, D. and Cloyd, M.W. Transient or occult HIV infection may occur more frequently than progressive infections: Changing the paradigm about HIV persistence. Arch Virol 2005;19:131-145.

Ø Huang, J.C., Ober, R.J., and Ward, E.S. The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis.  Eur J Immunol 2005. 35(1):299-304.

Ø Huang, J.C., Vestberg, M., Minguela, A., Holmdahl, R., Ward, E.S. Analysis of autoreactive T cells associated with murine collagen-induced arthritis using peptide-MHC multimersInt. Immunol. 2004. 16(2):283-93.

Ø Huang, J.C., Han, M., Minguela, A., Pastor, S., Qadri, A., Ward, E.S. T cell recognition of distinct peptide:I-Au conformers in murine experimental autoimmune encephalomyelitis. J. Immunol. 2003. 171(5):2467-77.

Ø Chen, J.J., Huang J.C., Shirtliff, M., Briscoe, E., Ali, S., Cesani, F., Paar, D., Cloyd, M.W. CD4 lymphocytes in the blood of HIV(+) individuals migrate rapidly to lymph nodes and bone marrow: support for homing theory of CD4 cell depletion. J. Leukoc. Biol. 2002. 72(2):271-8.

Ø Sahu, G.K., Chen, J.J., Huang, J.C., Ramsey, K.M., Cloyd, M.W. Transient or occult HIV-1 infection in high-risk adults. AIDS. 2001.15(9):1175-7.