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生技產業創新創業人才培育課程
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楊慕華 教授
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Muh-Hwa Yang. (楊慕華), M.D., Ph.D.

Professor

M.D., National Yang-Ming University, Taiwan

Ph.D., National Yang-Ming University, Taiwan

國立陽明大學臨床醫學研究所 專任教授

國立陽明大學醫學生物技術暨檢驗學系暨研究所 合聘教授

台北榮民總醫院內科部血液腫瘤科 主治醫師

 

 

 

(112)台北市北投區立農街二段155

國立陽明大學實驗大樓4302 臨床醫學研究所

 

Phone: 02-2826-7000 ext. 7911 (Office)
             02-2826-7000 ext. 5561 (Lab)

FAX: 02-2823-5870
E-mail: mhyang2@vghtpe.gov.tw; mhyang2@ym.edu.tw

Research Interests:

1.      Molecular mechanism of cancer metastasis

2.      Clinical oncology (head and neck cancer)

 

Honors

  • Dr. Ta-Cheng Tung Memorial Award for Basic Cancer Research, Chinese Oncology Society, Taiwan (2009) Distinguished thesis award, Taipei Veterans General Hospital (2009)
  • Ta-Yu Wu Memorial Award, National Science Council, Taiwan (2008)
  • Award of Distinguished Thesis, Tien-Te Lee Biomedical Foundation, Taiwan (2008)
  • Award of Distinguished Research Project, Taiwan Society of Hematology (2005)
  • Award of Distinguished Thesis, Taiwan Society of Hematology (2005, 2009)
  • Award of the Best Research Project, Joint Congress of Oncology Societies of Taiwan (2007, 2009, 2010)

Publications

A. Papers of Cancer Biology
  1. Yang MH*, Hsu DS, Wang HW, Wang SJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, Chang SY, Lee OK, Wu KJ. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol 2010; 12:982-992 (*: corresponding author).
  2. Hsu DS, Lan HY, Huang CH, Tai SK, Chang SY, Tsai TL, Chang CC, Tzeng CH, Wu KJ, Kao JY, Yang MH*. Regulation of excision repair cross-complementation group 1 (ERCC1) by Snail contributes to cisplatin resistance in head and neck cancer. Clin Cancer Res 2010; 16:4561-4571 (*: corresponding author).
  3. Chen YJ, Li SY, Huang CH, Twu NF, Yen MS, Wang PH, Chou TY, Liu YN, Chao KC, Yang MH*. Oestrogen-induced epithelial-mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis. J Pathol 2010; 222:261-270 (*: corresponding author).
  4. Hsu DS, Chang SY, Liu CJ, Tzeng CH, Wu KJ, Kao JY, Yang MH*. Identification of increased NBS1 expression as a prognostic marker of squamous cell carcinoma of oral cavity. Cancer Sci 2010; 101:1029-1037 (*: corresponding author).
  5. Huang CH, Chen PM, Lu TC, Kung WM, Chiou TJ, Yang MH, Kao JY, Wu KJ. Purified Recombinant TAT-HOXB4 expands CD34+ Umbilical Cord Blood and Peripheral Blood Progenitor Cells ex vivo. Tissue Eng Part C Methods 2010; 16:487-496.
  6. Huang CH, Yang WH, Chang SY, Tai SK, Tzeng CH, Kao JY, Wu KJ, Yang MH*. Regulation of membrane-type 4 matrix metalloproteinase (MT4-MMP) by SLUG contributes to hypoxia-mediated metastasis. Neoplasia 2009;11:1371-82 (*: corresponding author).
  7. Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL, Wu JC. Comprehensive analysis of the independent effect of Twist and Snail in promoting metastasis of hepatocellular carcinoma. Hepatology 2009; 50:1464-1474
  8. Hung JJ, Yang MH, Hsu HH, Hsu WH, Wu KJ. Prognostic significance of hypoxia-inducible factor-1 alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer. Thorax 2009; 64:1082-9.
  9. Tsai YP, Yang MH, Huang CH, Chang SY, Chen PM, Liu CJ, Teng SC, Wu KJ. Interaction between HSP60 and beta-catenin promotes metastasis. Carcinogenesis 2009; 30: 1049-57.
  10. Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008; 10:295-305.
  11. Yang MH, Wu KJ. TWIST activated by hypoxia inducible factor-1 (HIF-1): implication in metastasis and development. Cell Cycle 2008; 7:2090-2096.
  12. Chen PM, Yen CC, Wang WS, Lin YJ, Chu CJ, Chiou TJ, Liu JH, Yang MH*. Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia. Int J Oncol 2008; 32:1335-41 (*: corresponding author).
  13. Chang PM, Chen PM, Hsieh SL, Tzeng CH, Liu JH, Chiou TJ, Wang WS, Yen CC, Gau JP, Yang MH*. Expression of a soluble decoy receptor 3 (DcR3) in patients with diffuse large B cell lymphoma (DLBCL) predicts clinical outcome. Int J Oncol 2008; 33;549-554 (*: corresponding author).
  14. Chen YC, Chiang HY, Yang MH, Chen PM, Chang SY, Teng SC, Vanhaesebroeck B, Wu KJ. Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif. J Mol Med 2008; 86:401-12
  15. Yang MH, Chang SY, Chiou SH, Liu CJ, Chi CW, Chen PM, Teng SC, Wu KJ. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene 2007; 26:1459-1467.
  16. Lin HL†, Yang MH†, Wu CW, Chen PM, Yang YP, Chu YR, Kao CL, Ku HH, Lo JF, Liou JP, Chi CW, Chiou SH. 2-methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. Int J Cancer 2007; 121: 2547-55 (†: equal contributions).
  17. Yang MH, Chiang WC, Chou TY, Chang SY, Chen PM, Teng SC, Wu KJ. Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation. Clin Cancer Res 2006; 12: 507-515.
  18. Yang MH, Yen CC, Chiang SC, Bai LY, Lee KD, Hsiao LT, Chao TC, Wang WS, Liu JH, Chiou TJ, Chen PM. Prognostic significance of clonal diversity of immunoglobulin gene rearrangements in patients with diffuse large B-cell lymphoma. Oncol Rep 2005 13: 503-508.
  19. Liu JH, Yen CC, Lin YC, Gau JP, Yang MH, Chao TC, Hsiao LT, Wang WS, Tsai YC, Chen PM. Overexpression of cyclin D1 in accelerated-phase chronic myeloid leukemia. Leuk Lymphoma 2004; 45: 2419-2425.
  20. Chen PM, Yang MH, Hsiao LT, Yu IT, Chu CJ, Chao TC, Yen CC, Wang WS, Chiou TJ, Liu JH. Decreased FHIT protein expression correlates with a worse prognosis in patients with diffuse large B-cell lymphoma. Oncol Rep 2004; 11: 349-356.
  21. Liu JH, Wu SC, Chen WS, Yen CC, Yang MH, Tsai YC, Chen PM. An intron promotes the anti-bcr-abl activities of a retrovirally expressed ribozyme in chronic myeloid leukemia cells. Biochem Biophys Res Commun 2004; 318:764-772.
  22. Lin JT, Wu MS, Wang WS, Yen CC, Chiou TJ, Liu JH, Yang MH, Chao TC, Chou SC, Chen PM. All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia. Adv Ther 2003; 20:337-343.
  23. Yen CC, Chen YJ, Lu KS, Hsia JY, Chen JT, Hu CP, Chen PM, Liu JH, Chiou TJ, Wang WS, Yang MH, Chao TC, Lin CH. Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. Int J Oncol 2003; 23:871-881.
  24. Chen PM, Yang MH, Yu IT, Lin JT, Lin YC, Fan FS, Wang WS, Yen CC, Chiou TJ, Liu JH. Low incidence of BCL-6 gene alterations for diffuse large B cell lymphomas in Taiwan Chinese. Cancer 2002; 94:2635-2644.
  25. Chen PM, Chiou TJ, Yu IT, Fan FS, Chu CJ, Kao SC, Wang WS, Liu JH, Hsu WM, Yang MH, Chao TC, Tai CJ, Hsiao LT, Lin JT, Yen CC. Molecular analysis of mucosa-associated lymphoid tissue (MALT) lymphoma of ocular adnexa. Leukemia Lymphoma 2001; 42:207-214.
B. Papers of Clinical Oncology
  1. Chen MH, Chang PM, Chen PM, Tzeng CH, Chu PY, Chang SY, Yang MH*. Prolonged facial edema is an indicator of poor prognosis in patients with head and neck squamous cell carcinoma. Support Care Cancer 2010; 18:1313-1319 (*: corresponding author).
  2. Huang YC, Chang PM, Lee IC, Yang CF, Tzeng CH, Yang MH*. Duodenal squamous cell carcinoma derived from the hypopharynx - immunohistochemical assessment of metastatic mechanisms. Gastrointest Endosc 2010; 72:460-463(*: corresponding author).
  3. Chen MH, Chang PM, Chen PM, Tzeng CH, Chu PY, Chang SY, Yang MH*. Prognostic significance of a pretreatment hematologic profile in patients with head and neck cancer. J Cancer Res Clin Oncol2009;135:1783-90 (*: corresponding author).
  4. Yang MH, Chang PM, Tzeng CH, Chang SY, Chu PY, Tai SK, Tsai TL, Wang YF, Huang JL, Wang HM, Chen PM. Promising overall survival of patients with recurrent/metastatic squamous cell carcinoma of head and neck receiving gemcitabine plus cisplatin treatment: report of a multi-center phase II study. Cancer Chemother Pharmaco 2010; 65: 259-265.
  5. Liu CY, Huang LJ, Wang WS, Chen TL, Yen CC, Yang MH, Hsiao LT, Liu CY, Chen PM, Chiou TJ. Candidemia in cancer patients: impact of early removal of non-tunneled central venous catheters on outcome. J Infect 2009; 58: 154-60.
  6. Chang PM, Chen PM, Chu PY, Wang LW, Tai SK, Tsai TL, Huang JL, Wang YF, Chang SY, Yang MH*. Effectiveness of pharmacokinetic modulating chemotherapy combined with cisplatin as induction chemotherapy in resectable locally advanced head and neck cancer: phase II study. Cancer Chemother Pharmacol 2008; 63:9-17 (*: corresponding author).
  7. Lee MY, Chiou TJ, Hsiao LT, Yang MH, Lin PC, Poh SB, Yen CC, Liu JH, Teng HW, Chao TC, Wang WS, Chen PM. Rituximab therapy increased post-transplant cytomegalovirus complications in Non-Hodgkin's lymphoma patients receiving autologous hematopoietic stem cell transplantation. Ann Hematol 2008; 87: 285-9.
  8. Tai SK, Yang MH, Wang LW, Tsai TL, Chu PY, Wang YF, Huang JL, Chang SY. Chemoradiotherapy laryngeal preservation for advanced hypopharyngeal cancer. Jpn J Clin Oncol 2008; 38:521-7.
  9. Chang PM, Teng HW, Chen PM, Chang SY, Chu PY, Tsai TL, Tai SK, Wang YF, Huang JL, Yang MH*. Methotrexate and leucovorin double-modulated 5-fluorouracil combined with cisplatin (MPFL) in metastatic/recurrent head and neck cancer. J Chin Med Assoc 2008; 71:336-341 (*: corresponding author).
  10. Lee MY, Yang MH, Liu JH, Yen CC, Lin PC, Teng HW, Wang WS, Chiou TJ, Chen PM. Severe anaphylactic reactions in patients receiving oxaliplatin therapy: a rare but potentially fatal complication. Support Care Cancer 2007;15:89-93.
  11. Hsiao LT, Chiou TJ, Liu JH, Chu CJ, Lin YC, Chao TC, Wang WS, Yen CC, Yang MH, Tseng CH, Chen PM. Extended lamivudine therapy against hepatitis B virus infection in hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant 2006;12: 84-94.
  12. Chen PM, Yen CC, Yang MH, Poh SB, Hsiao LT, Wang WS, Lin PC, Lee MY, Teng HW, Bai LY, Chu CJ, Chao SC, Yang AH, Chiou TJ, Liu JH, Chao TC. High prevalence of SV40 infection in patients with nodal non-Hodgkin's lymphoma but not acute leukemia independent of contaminated polio vaccines in Taiwan. Cancer Invest 2006; 24: 223-228.
  13. Lin PC, Lee MY, Wang WS, Yen CC, Chao TC, Hsiao LT, Yang MH, Chen PM, Lin KP, Chiou TJ. N-acetylcysteine has neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients: preliminary data. Support Care Cancer 2006;14: 484-487.
  14. Lin PC, Wang WS, Yang MH, Yen CC, Chao TC, Hsaio LT, Chen PM. Sequential therapy with capecitabine followed by vinorelbine/cisplatin in patients with anthracycline/taxane-refractory metastatic breast cancer. J Chin Med Assoc 2006;69:304-309.
  15. Lin JT, Wang WS, Yen CC, Liu JH, Yang MH, Chao TC, Chen PM, Chiou TJ. Outcome of colorectal carcinoma in patients under 40 years of age. J Gastroenterol Hepatol 2005; 20:900-905.
  16. Chao TC, Chu Z, Tseng LM, Chiou TJ, Hsieh RK, Wang WS, Yen CC, Yang MH, Hsiao LT, Liu JH, Chen PM. Paclitaxel in a novel formulation containing less Cremophor EL as first-line therapy for advanced breast cancer: a phase II trial. Invest New Drugs 2005; 23:171-177.
  17. Lee MY, Chiou TJ, Yang MH, Bai LY, Hsiao LT, Chao TC, Tung SL, Wang WS, Yen CC, Liu JH, Chen PM. Relatively favorable outcomes of post-transplant pulmonary function in patients with chronic myeloid leukemia receiving non-myeloablative allogeneic hematopoietic stem cell transplantation. Eur J Haematol 2005; 74:152-157.
  18. Peng KL, Chen SJ, Lin PY, Hsu WM, Yang MH, Tzeng CH, Chen PM. Exudative bullous retinal detachment after peripheral blood stem cell transplantation. Eye 2005;19: 603-606.
  19. You JY, Chi KH, Yang MH, Chen CC, Ho CH, Chau WK, Hsu HC, Gau JP, Liu JH, Chen PM, Chiou TJ. Radiation therapy versus chemotherapy as initial treatment for localized nasal natural killer (NK)/T-cell lymphoma: a single institute survey in Taiwan. Ann Oncol 2004 ;15:618-625.
  20. Bai LY, Chiou TJ, Liu JH, Yen CC, Wang WS, Yang MH, Hsiao LT, Chao TC, Chen PM. Hematopoietic stem cell transplantation for severe aplastic anemia-experience of an institute in Taiwan. Ann Hematol 2004; 83:38-43.
  21. Lin JT, Lee MY, Hsiao LT, Yang MH, Chao TC, Chen PM, Chiou TJ. Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation. Ann Hematol 2004; 83:444-446.
  22. Bai LY, Yang MH, Chiou TJ, Liu JH, Yen CC, Wang WS, Hsiao LT, Chao TC, Chen PM. Non-Hodgkin lymphoma in elderly patients: experience at Taipei Veterans General Hospital. Cancer 2003; 98:1188-1195.
  23. Lin JT, Wang WS, Yen CC, Liu JH, Chiou TJ, Yang MH, Chao TC, Chen PM. Chryseobacterium indologenes bacteremia in a bone marrow transplant recipient with chronic graft-versus-host disease. Scand J Infect Dis 2003; 35:882-883.
  24. Yang MH, Chiou TJ, Chao TC, Hsiao LT, Chen PM. Delayed rejection after initial engraftment in non-myeloablative bone marrow transplantation. J Chin Med Assoc 2003;66: 682-688 .
  25. Yang MH, Yen CC, Chen PM, Wang WS, Chang YH, Huang WJS, Fan FS, Chiou TJ, Liu JH, Chen KK. A prognostic-factors-based risk-stratification model for invasive urothelial carcinoma of the urinary bladder in Taiwan. Urology 2002; 59:232-238.
  26. Yang MH, Chen KK, Yen CC, Wang, WS, Chang YH, Huang WJS, Fan FS, Chiou TJ, Liu JH, Chen PM. Unusual high incidence of upper-urinary-tract urothelial carcinoma in Taiwan. Urology 2002; 59:681-687.
  27. Chen PM, Yao NS, Wu CM, Yang MH, Lin YC, Hsiao LT, Yen CC, Wang WS, Fan FS, Chiou TJ, Liu JH, Lo SJ. Detection of reactivation and genetic mutations of the hepatitis B virus in patients with chronic hepatitis B infections receiving hematopoietic stem cell transplantation. Transplantation 2002; 74:282-288.
  28. Lin JT, Wang WS, Yen CC, Chiou TJ, Liu JH, Hsiao LT, Yang MH, Chao TC, Tai CJ, Chen PM. Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. Ann Hematol 2002 ; 81:723-726.
  29. Lin JT, Wang WS, Yen CC, Chiou TJ, Liu JH, Hsiao LT, Yang MH, Chao TC, Tai CJ, Chen PM. Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. Ann Hematol 2002; 81:723-726.
  30. Chen YC, Chiou TJ, Yang MH, Yu IT. Two easy-to-perform diagnostic tests for Gilbert’s syndrome. Chin Med J (Taipei) 2002;65:231-234
  31. Yang MH, Hsu HC. Pure red cell aplasia after ABO-incompatible allogeneic stem cell transplantation in severe aplastic anemia with response to steroids: a case report and literature review. Ann Hematol 2001; 80:299-301.
  32. Liu JH, Yang MH, Fan FS, Yen CC, Wang WS, Chang YH, Chen KK, Chen PM. Tamoxifen and colchicine-modulated vinblastine followed by 5-fluorouracil in advanced renal cell carcinoma : a phase II study. Urology 2001; 57: 650-654.
  33. Hung GY, Chiou TJ, Hsieh YL, Yang MH, Chen WYK. Intestinal metastasis causing intussusception in a patient treated for osteosarcoma with history of multiple metastases: a case report. Jpn J Clin Oncol 2001; 31: 165-167.
  34. Yang MH, Ho CH. 2-Chlorodeoxyadenosine (Cladribine) in the treatment of hairy cell leukemia. Chin Med J (Taipei) 2001;64: 54-58.
  35. Yang MH, Yen CC, Chang YH, Hsieh RK, Liu JH, Chiou TJ, Fan FS, Lin ATL, Huang WJS, Wang WS, Chen KK, Chen PM. Single agent paclitaxel as a first-line therapy in advanced urothelial carcinoma : its efficacy and safety in patients even with pretreatment renal insufficiency. Jpn J Clin Oncol 2000; 30: 547-552.
  36. Yang MH, Fan FS, Chen PM, Liu JH, Chiou TJ, Wang WS, Yen CC. Venous gangrene in a patient with adenocarcinoma of lung. Jpn J Clin Oncol 2000; 30: 276-278.
  37. Yen CC, Liu JH, Wang WS, Fan FS, Chiou TJ, Tai CJ, Yang MH, Chao TC, Hsiao LT, Chen PM. Immunophenotypic and genotypic characteristics of chronic myelogenous leukemia in blast crisis. Chin Med J (Taipei) 2000; 63: 785-791.