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生技產業創新創業人才培育課程
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張 正 教授

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張正  

教授

聯絡電話:02-28267000#7943

傳真號碼:02-2820-1093

地址:台北市北投區112立農街二段155號研究大樓6604

國立陽明大學生物醫學暨工程學院辦公室

E-mailcachang@ym.edu.tw



學歷
國立台灣大學化學系學士(1970-74)
美國匹茲堡大學生物無機及分析化學博士(1974-78)

經歷
美國衛斯理女子學院化學系助理教授(1978-79)
美國麻省理工學院化學系訪問學者(1978-79)
美國德州大學化學系助理教授(1980-1985)、終生職副教授(1985-88)
美國鋁業公司層析及生物科技組長(1986-87)
美國必治妥施貴寶大藥廠診斷藥劑研究組長(1987-90)
美國Nycomed Salutar生物科技公司研發副總裁(1990-92)
美國天虹(Grace)醫藥科技顧問公司總裁(1992-94)
美國Frost & Sullivan醫藥情報公司醫藥及生物科技情報部主任(1992-93)
台南南光化學製藥公司資深顧問(1993-94)
美國國家衛生研究院無機生物化學研究小組委員(1990-94)、諮詢委員(1994-98)
美國化學會Bioconjugate Chemistry期刊編審委員(1992-97)
台灣國立交通大學生物科暨研究所籌備主任(1993)、教授(1994-今)兼創所所長(1994-99)
經濟部、國科會、原能會、教育部、衛生署、農委會、工研院、自強基金會等政府部會、財團法人、私人公司、文教團體顧問或審查委員(1995-今)
五鼎生技公司(2003-2009)、生揚生技創投公司(2005-今)、立弘生技公司(2003-今)、 懷特生技公司(2001-04)獨立董事、百泰生技公司監察人(2003-2008)
國立陽明大學生物醫學影像暨放射科學系教授 (2009-今)
國立陽明大學生物醫學暨工程學院院長 (2009-今)
國立陽明大學生醫科學暨工程跨領域學位學程主任 (2009-今)

研究興趣
製藥、化學、生物科技之企業、學術行政管理及經營;體內診斷及免疫藥劑之研究及發展;
分析化學、分離及純化技術;生物無機化學、稀土離子配位化學;
醫學診斷、製藥、生物科技之市場情報研究、行銷及企畫

論文著作
1. T.M. Hseu, Chang and K.L. Hsu. "Spectrophotometric studies of Uranyl (VI)Chelate of β-Isopropyltropolone", J. Chinese Chem. Soc., 1977, 24, 11-19. [SCI:0.643; Rank: 90/120]
2. G.G. Hawn, Chang and B.E. Douglas. "Circular Dichroism and Carbon-13 Nuclear Magnetic Resonance Studies of Some Phenyl Substituted Ethylenediamine -N,N,N',N'-tetraacetate Analogs", Inorg. Chem., 1979, 18, 1266-1271. [SCI: 4.123; Rank: 4/43; No. of Citations: 25 ]
3. Chang and B.E. Douglas. "Stereochemical Studies of Cobalt(III) Complexes ofSexi-dentate Aminopolyacids Using Carbon-13 Chemical Shifts", J. Coord. Chem., 1979, 9, 93-106. [SCI: 0.867; Rank: 29/43; No. of Citations: 13 ]
4. D.E. Bause, Chang and B.E. Douglas. "Carbon-13 Nuclear Magnetic Resonance Studies of Cobalt(III) Complexes of Ethylenediamine-N,N,N'-triacetate Type Ligands", J. Coord. Chem., 1979, 9, 211-219. [SCI: 0.867; Rank: 29/43; No. of Citations: 6 ]
5. Chang and B.E. Douglas. "Carbon-13 Nuclear Magnetic Resonance Study of Polar-(nitro)-trimethylenediamine-N,N,N'-triacetatocobaltate (III) Ion", J. Coord. Chem., 1980, 10, 131-134. [SCI: 0.867; Rank: 29/43; No. of Citations: 1 ]
6. Chang and H.H. Patterson. "Halide Ion Enhancement of Chromium (III) , Iron(II), and Cobalt(II) catalysis of Luminol Chemiluminescence", Anal. Chem., 1980, 52, 653-656. [SCI: 5.287; Rank: 2/70; No. of Citations: 38 ]
7. Chang, H.H. Patterson, L.M. Mayer, and D.E. Bause. "Determination of Trivalent Chromium in Sea Water by Chemiluminescence", Anal. Chem., 1980, 52, 1264-1267. [SCI: 5.287; Rank: 2/70; No. of Citations: 29 ]
8. Chang, R.B. Marcotte, and H.H. Patterson. "The Platinum Phthalimide Blues: Synthesis and Physical Characterization. Hush Model Interpretation of optical Spectra",Inorg. Chem., 1981, 20, 1632-1636. [SCI: 4.123; Rank: 4/43; No. of Citations: 13 ]
9. Chang* and B.E. Douglas . "Stabilities of Complex Formation Between Triethylene-teraamine-N2,N3-Diacetic Acid and Some Transition Metal Ions", J. Coord. Chem., 1981, 11, 91-97. [SCI: 0.867; Rank: 29/43; No. of Citations: 12 ]
10. Chang* and C.F. Tu. "High Performance Liquid Chromatographic Selectivities ofDihydroxybenzenes Using Silica, Diamine, and Cobalt Complex Bonded Phase Columns", Anal. Chem., 1982, 54, 1179-1182. [SCI: 5.287; Rank: 2/70; No. of Citations: 15 ]
11. Chang. "Thermodynamic Parameters of Liquid Chromatographic separations of Fructose, Glucose, and Sucrose with Amine and Cobalt Complex Bonded Phases", Anal. Chem., 1983, 55, 971-974. [SCI: 5.287; Rank: 2/70; No. of Citations: 10]
12. Chang*, C.S. Huang, and C.F. Tu. "Characterization of Substitution-Inert Cobalt (III) Complex Bonded Phases in Liquid Chromatography", Anal. Chem., 1983, 55, 1390-1395. [SCI: 5.287; Rank: 2/70; No. of Citations: 10]
13. L.M. Mayer, L. Shick, and Chang. "Kinetics of Trivalent Chromium Complexationand Adsorption at the River-Estuary Interfaces: Implications for Reactive Pollutant Transport", Heavy Met. Environ., Int. Conf., 4th, 1983, 2, 1112-1115.
14. Chang* and M.E. Rowland. "Metal Complex Formation with 1,10-Diaza-4,7,13,16-Tetraoxacyclooctadecane-N,N'-Diacetic Acid, An Approach to Potential Lanthanide Ion Selective Reagents", Inorg. Chem., 1983, 22, 3866-3869. [SCI: 4.123; Rank: 4/43; No. of Citations: 71 ]
15. D.V. Marquez, R. Aguilar, and Chang*. "An Automated Reagent Addition System with an Infrared Drop Detector", J. Chinese Chem. Soc. 1984, 31, 205-209. [SCI: 0.643; Rank: 90/120]
16. Chang, E.N. Duesler, and R.E. Tapscott. "The Crystal and Molecular Structure of 1,9-Diamino-4-Methyl-3,7-Diazanonane-3,7-Diacetatocobalt(III) Nitrate Monohydrate - A Complex Exhibiting Large 13C NMR Steric Shift", Inorg. Chim. Acta, 1984, 85, 73-78. [SCI: 1.713; Rank: 18/43; No. of Citations: 1 ]
17. Chang*, C.F. Tu, and C.S. Huang. "Normal Phase Separation of Chloroanilinesand Nitroanilines with Silica, Amine, and Cobalt(III) Complex Bonded Phases", J.Chromatogr. Sci., 1984, 22, 321-326. [SCI: 0.869; Rank: 51/70; No. of Citations: 8 ]
18. Chang*, C.S. Huang, and J.M. Hoffer. "Determination of Silica Surface-Confined Cobalt by Energy Dispersive X-Ray Fluorescence Spectrometry", Analyst, 1984, 109, 99-100. [SCI: 3.553; Rank: 7/70; No. of Citations: 1 ]
19. L.M. Mayer, L.L. Schick, and Chang. "Incorporation of Trivalent Chromium intoRiverine and Estuarine Colloidal Material", Geochimica et Cosmochimica Acta, 1984, 48, 1717-1722. [SCI: 3.665; Rank: 4/63; No. of Citations: 15 ]
20. Chang* and K.L. Fong. "Substitution-Inert Metal Complex Mobile Phases in Non-Suppressed Anion Chromatography", J. Chromatogr., 1984, 312, 99-107. [SCI: 3.641; Rank: 5/70; No. of Citations: 2 ]
21. Chang* and C.S. Huang. "Effect of Solvent Composition and Temperature on the Separation of Anilines with Silica, Amine, and Diamine Bonded Phase Columns", Anal. Chem., 1985, 57, 997-1005. [SCI: 5.287; Rank: 2/70; No. of Citations: 19 ]
22. Chang* and L.D. Tan. "Effects of Solvent Composition and Temperature on the Normal Phase Liquid Chromatographic Separation of Phenols", J. Liq. Chromatogr., 1985, 8, 995-1007. [SCI: 0.977; Rank: 49/70; No. of Citations: 9 ]
23. Chang*, C.S. Huang, and P.D. Murphy. "Synthesis and Spectroscopic Characterization of Substitution-Inert Cobalt(III) Complex Bonded Silicas", Inorg. Chem., 1985, 24, 4216-4218. [SCI: 4.123; Rank: 4/43; No. of Citations: 2 ]
24. Chang*, H. Abdel-Aziz, N. Melchor, Q. Wu, K.H. Pannell, and D.W. Armstrong. "Liquid Chromatographic Retention Behavior of Organometallic Compounds and Ligandswith Amine, Octadecylsilica, and β-Cyclodextrin Bonded Phase Columns", J.Chromatogr., 1985, 347, 51-60. [SCI: 3.641; Rank: 5/70; No. of Citations: 23 ]
25. Chang*. V.O. Ochaya, and V.C. Sekhar. "Unusual Thermodynamic and Kinetic Properties of Lanthanide Complexes of 1,7-Diaza-4,10,13-Trioxacyclopentadecane -N,N'-Diacetic Acid", J. C. S. Chem. Commun., 1985, 1724-1725. [SCI: 5.141; Rank: 11/120; No. of Citations: 26 ]
26. Chang*. J. Twu, and R.A. Bartsch. "pH-Dependent Metal Selectivity by a CrownEther Carboxylic Acid", Inorg. Chem., 1986, 25, 396-398. [SCI: 4.123; Rank: 4/43; No. of Citations: 18 ]
27. Chang* and V.O. Ochaya. "Potential Lanthanide Ion Selective Reagents III. Metal Complex Formation with 1,7-Diaza-4,10,13-Trioxacyclopentadecane-N,N' -DiaceticAcid", Inorg. Chem, 1986, 25, 355-358. [SCI: 4.123; Rank: 4/43; No. of Citations: 67]
28. Chang*, B.S. Garg, V.K. Manchanda, V.O. Ochaya, and V.C. Sekhar. "MixedLigand Complexes of Lanthanides with Macrocyclic and Open-chained Aminopolyacidsand Acetylacetone", Inorg. Chim. Acta, 1986, 115, 101-106. [SCI: 1.713; Rank: 18/43; No. of Citations: 13]
29. Chang*, Q. Wu, and D.W. Armstrong. "Reversed Phase HPLC Separation of Substituted Phenolic Compounds with a β-Cyclodextrin Bonded Phase Column", J.Chromatogr., 1986, 354, 454-458. [SCI: 3.641; Rank: 5/70; No. of Citations: 59]
30. V.C. Sekhar and Chang*. "Dissociation Kinetics of 1,7-Diaza-4,10,13-Trioxacyclopenta-decane-N,N'-Diacetic Acid Complexes of Lanthanides", Inorg. Chem., 1986, 25, 2061-2065. [SCI: 4.123; Rank: 4/43; No. of Citations: 39]
31. Chang*, Q. Wu, and L. Tan. "Normal Phase HPLC Separations of Positional Isomers of Substituted Benzoic Acids with Amine and β-Cyclodextrin Bonded Phase Columns", J. Chromatogr., 1986, 361, 199-207. [SCI: 3.641; Rank: 5/70; No. of Citations: 35]
32. V.K. Manchanda and Chang*. "Solvent Extractions of Lanthanum(III) and Neodymium(III) with Ionizable Macrocyclic Ligands and Thenoyltrifluoroacetone", Anal. Chem., 1986, 58, 2269-2275. [SCI: 5.287; Rank: 2/70; No. of Citations: 30]
33. Chang* and Q. Wu. "Comparison of Liquid Chromatographic Separations of Geometrical Isomers of Substituted Phenols with β- and γ- Cyclodextrin Bonded Phase Columns", Anal. Chim. Acta, 1986, 189, 293-299. [SCI: 3.186; Rank: 10/70; No. of Citations: 25 ]
34. M.P. Eastman, B. Freiha, B. Kessel, and Chang. "Magnetohydrodynamics ofNematic Mesophases by ESR", Liquid Crystals, 1986, 1, 147-153. [SCI:1.362; Rank: 11/25; No. of Citations:1 ]
35. Chang*, Q. Wu, and M.P. Eastman. "Effects of Mobile Phases on the Separation of Substituted Anilines with a Cyclodextrin Bonded Phase Column", J. Chromatogr., 1986, 371, 269-282. [SCI: 3.641; Rank: 5/70; No. of Citations: 17]
36. Chang*, V.C. Sekhar, B.S. Garg, F.S. Guziec, Jr., and T.C. Russo. "Equilibria and Kinetics of Some Metal Complexes of Peptide Hydroxamic Acids", Inorg. Chim. Acta, 1987, 135, 11-18. [SCI: 1.713; Rank: 18/43; No. of Citations: 8 ]
37. M.P. Eastman, B. Freiha, C.C. Hsu, K.C. Lum, and Chang. "Weak Complexationof Nitroxide Radicals by Cyclodextrins", J. Phys. Chem., 1987, 91, 1953-1956. [SCI: 4.086; Rank: 11/110; No. of Citations: 23 ]
38. Chang* and Q. Wu. "Facile Liquid Chromatographic Separation of Geometrical Isomers with γ-Cyclodextrin Bonded Phase Column", J. Liq. Chromatogr., 1987, 10, 1359-1368. [SCI: 0.977; Rank: 49/70; No. of Citations: 15 ]
39. V.K. Manchanda and Chang*. "Solvent Extraction Studies of Europium (III),Ytterbium(III), and Lutetium(III) with Ionizable Macrocyclic Ligands andThenoyltrifluoroacetone", Anal. Chem., 1987, 59, 813-818. [SCI: 5.287; Rank: 2/70; No. of Citations: 30 ]
40. Chang* and V.C. Sekhar. "Dissociation Kinetics of 1,10-Diaza-4,7,13,16-Tetraoxacyclooctadecane-N,N'-Diacetic Acid Complexes of Lanthanides", Inorg. Chem., 1987, 26, 1981-19685. [SCI: 4.123; Rank: 4/43; No. of Citations: 36 ]
41. C.A. Chang*, H. Ji, Q. Wu, M.P. Eastman, and S.T.J. Lai. "Use of CyclodextrinBonded Columns for the Liquid Chromatographic Separation of Styrene Polymers", Anal.Chim. Acta, 1987, 194, 287-292. [SCI: 3.186; Rank: 10/70; No. of Citations: 2 ]
42. Z. Pang, C.A. Chang*, and E. Wang. "The Study on the Transfer of the Basic Electrolyte Ion TBA+ Across the Water/Nitrobenzene Interface by Linear Current-Scanning Method", J. Electroanal. Chem., 1987, 234, 71-84. [SCI: 2.580; Rank: 21/70; No. of Citations: 8 ]
43. V.C. Sekhar, Chang*, and S. Sherman . "Kinetics of Acid-Catalyzed Dissociation of Lead(II) and Copper(II) Complexes of Ethylenebis(Oxyethylene-nitrilo)tetraaceticAcid (EGTA)", Inorg. Chim. Acta, 1987, 130, 157-162. [SCI: 1.713; Rank: 18/43]
44. Chang*, V.K. Manchanda, and J. Peng. "Macrocyclic Reagents for the kinetic Control of Chelate Extraction Selectivities of Lanthanides ", Inorg. Chim. Acta, 1987, 130, 117-118. [SCI: 1.713; Rank: 18/43; No. of Citations: 14]