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涂玉青

l 職稱:助理教授

l 地址:(112) 台北市北投區石牌立農街二段155
        國立陽明大學 醫學生物技術暨檢驗學系

l E-mailyctwu@ym.edu.tw

l 電話: 02-2826-7000 ext. 7294 (Office)
         02-2826-7000 ext. 5831 (Lab)

 

l 學歷

2003.9~2008.1: 台灣大學生化科學所 博士

1997.9~1999.8: 陽明大學醫學生物技術暨檢驗學研究所 碩士

1993.9~1997.6: 陽明大學醫學技術學系 學士

 

l 經歷

2011.7~2012.7: 博士後研究  Terry Fox Laboratory, BC Cancer Agency

2008.11~2011.6: 博士後研究  Department of Microbiology and Immunology, University of British Columbia

2008.2~2008.10: 博士後研究 台灣大學 生化科學所

 

l 教授科目

血庫學、血液學、臨床血液學、血液學及血庫學實驗

 

l 研究領域

自然殺手細胞屬於免疫系統中非專一性防禦系統,負責毒殺受感染細胞和腫瘤細胞。其藉由表面的 stimulatory receptor inhibitor receptor 與目標細胞上的ligand結合,此結合可分別誘發活化或抑制性訊號,此兩者訊號的強弱調控其毒殺活性。

探討:

1. 自然殺手細胞對白血病細胞的毒殺作用機轉

2. 癌細胞躲避免疫監測系統中自然殺手細胞毒殺作用的機轉

3. 細胞表面醣結構的變化對自然殺手細胞表面接受器的辨識及毒殺功能的影響

 

l 研究著作

Ø Twu TC* and Teh HS. 2014. The ThPOK transcription factor differentially affects the development and function of self-specific CD8+ T cells and regulatory CD4+ T cells. Immunology 141: 431-45 

Ø Twu YCGold MR, Teh HS. 2011. TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells. Eur J Immunol 41: 335- 44

Ø Twu YCHsieh CY, Lin M, Tzeng CH, Sun CF, Yu LC. 2010. Phosphorylation status of transcription factor C/EBPalpha determines cell-surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis. Blood 115: 2491-9

Ø Wang HR, Hsieh CY, Twu YCYu LC. 2008. Expression of the human Sd(a) beta-1,4-N- acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status. Glycobiology 18: 104-13

Ø Twu YCChen CP, Hsieh CY, Tzeng CH, Sun CF, Wang SH, Chang MS, Yu LC. 2007. I branching formation in erythroid differentiation is regulated by transcription factor C/EBPalpha. Blood 110: 4526-34

Ø Twu YCHsieh CY, Yu LC. 2006. Expression of the histo-blood group B gene predominates in AB- genotype cells. Transfusion 46: 1988-96

Ø Lin M, Hou MJ, Twu YCYu LC. 2005. A novel A allele with 664G>A mutation identified in a family with the Am phenotype. Transfusion 45: 63-9

Ø Yu LC, Twu YCChou ML, Reid ME, Gray AR, Moulds JM, Chang CY, Lin M. 2003. The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts. Blood 101: 2081-8

Ø Twu YCChou ML, Yu LC. 2003. The molecular genetics of the mouse I beta-1,6-N- acetylglucosaminyltransferase locus. Biochem Biophys Res Commun 303: 868-76

Ø Sun CF, Yu LC, Chen IP, Chou DL, Twu YCWang WT, Lin M. 2003. Molecular genetic analysis for the Ae1 and A3 alleles. Transfusion 43: 1138-44

Ø Yu LC, Twu YCChou ML, Chang CY, Wu CY, Lin M. 2002. Molecular genetic analysis for the B(3) allele. Blood 100: 1490-2

Ø Yu LC, Twu YCChang CY, Lin M. 2001. Molecular basis of the Kell-null phenotype: a mutation at the splice site of human KEL gene abolishes the expression of Kell blood group antigens. J Biol Chem 276: 10247-52

Ø Yu LC, Twu YCChang CY, Lin M. 2001. Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen. Blood 98: 3840-5 

Ø Yu LC, Chu CC , Chan YS, Chang CY, Twu YCLee HL, Lin M. 2001. Polymorphism and distribution of the Secretor alpha(1,2)-fucosyltransferase gene in various Taiwanese populations. Transfusion 41: 1279-84

Ø Yu LC, Chang CY, Twu YCLin M. 2000. Human histo-blood group ABO glycosyltransferase genes: different enhancer structures with different transcriptional activities. Biochem Biophys Res Commun 273: 459-66

 

Ø Hsu HY, Twu YC2000. Tumor necrosis factor-alpha -mediated protein kinases in regulation of scavenger receptor and foam cell formation on macrophage. J Biol Chem 275: 41035-48